However, doxepin has the potential to cause side effects that fall into various categories, including those below: Anticholinergic effectsĪnticholinergic actions involve blocking the effect of a chemical called acetylcholine, which is the chief neurotransmitter of the parasympathetic nervous system (PNS). Somnolence refers to a state of drowsiness or a strong desire to sleep. The most frequent side effects are headaches and somnolence. They should also tell their doctor about any allergies, health conditions, and other drugs or nutritional supplements they take. People should follow the dosage directions carefully to avoid an overdose. A person should not take doxepin for longer than 4–8 weeks. The dosing for insomnia is 3–6 mg daily within 30 minutes of bedtime. What dosage is used for treating insomnia? Older research from 2014 involving 571 adults suggests that a very low dose of doxepin increases sleep duration but does not significantly affect sleep onset in adults and older adults. The Food and Drug Administration (FDA) has approved doxepin for the treatment of insomnia, especially if the person has trouble with sleep maintenance. Neurotransmitters are chemicals that send messages among brain cells.ĭoctors prescribe doxepin to treat insomnia and the following conditions: Share on Pinterest George Marks/Retrofile/Getty Imagesĭoxepin (Silenor) is a tricyclic antidepressant, a class of medication that increases certain neurotransmitters in the brain.
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